Dr. Rupam Sharma
Principal Scientist
Fish Genetics and Biotechnology
M. F. Sc, Ph.D.

+91 022 2636-1447 | Extn: 467 (O)

rupams@cife.edu.in

Research Interests

  • Nanotechnology in genetics and breeding
  • Molecular genetics

Research Papers

  • Pravesh Kumar, K. S. Wisdom, Gulshan Kumar, P. GireeshBabu, Sunil Kumar Nayak, N. S. Nagpure and Rupam Sharma, 2020. Ontogenetic and tissue‑specifc expression of gonadotropin‑inhibitory hormone (GnIH) and its receptors in Catla catla. Molecular Biology Reports https://doi.org/10.1007/s11033-020-05388-5.
  • Wisdom, K.S., Bhat, I.A., Chanu, T.I., Kumar, P., Pathakota, G.B., Nayak, S.K., Walke, P. and Sharma, R., 2020. Chitosan grafting onto single-walled carbon nanotubes increased their stability and reduced the toxicity in vivo (catfish) model. International Journal of Biological Macromolecules. Volume:155, Pages:697-707
  • Kumar, P., Wisdom, K.S., Bhat, I.A., Pathakota, G.B., Nayak, S.K., Reang, D., Nagpure, N.S. and Sharma, R., 2019. Molecular characterization of gonadotropin-inhibitory hormone (GnIH) gene and effect of intramuscular injection of GnIH peptide on the reproductive axis in Catla catla. Animal biotechnology, pp.1-15.
  • Rao, B.M., Kole, S., Gireesh-Babu, P., Sharma, R., Tripathi, G. and Bedekar, M.K., 2019. Evaluation of persistence, bio-distribution and environmental transmission of chitosan/PLGA/pDNA vaccine complex against Edwardsiella tarda in Labeo rohita. Aquaculture, 500, pp.385-392
  • Bhat, I. A., Ahmad, I., Nazir, M. I., Bhat. R.A.H., Pathakota, G. B., Goswami, M., Sundaray, J.K., Sharma R. (2018). Chitosan-eurycomanone nanoformulation acts on steroidogenesis pathway genes to increase the reproduction rate in fish. J. Steroid Biochem. Mol. Biol. 185:237-247.
  • Bhat, I. A., Nazir, M. I., Ahmad, I., Pathakota, G. B., Chanu, T. I., Goswami, M., Sharma R. (2018). Fabrication and characterization of chitosan conjugated eurycomanone nanoparticles: In vivo evaluation of the biodistribution and toxicity in fish. Int. J. Boil. Macromol. 112:1093-1103.
  • Sajal Kole, Ranjeeta Kumari, Deepika Anand, Saurav Kumar, Rupam Sharma, Gayatri Tripathi, M. Makesh, K.V. Rajendran, Megha Kadam Bedekar, 2018. Nanoconjugation of bicistronic DNA vaccine against Edwardsiella tarda using chitosan nanoparticles: Evaluation of its protective efficacy andimmune modulatory effects in Labeo rohita vaccinated by differentdelivery routes. Vaccine, 36(16), 2155-2165.
  • Wisdom, K.S., Bhat I.A., Kumar, P., Pathan, M., Chanu, T.I., Walke, P. and Sharma, R., 2018. Fabrication of chitosan nanoparticles loaded with aromatase inhibitors for the advancement of gonadal development in Clarias magur (Hamilton, 1822). Aquaculture, 497 (2018) 125–133.
  • Saha, R., Bhat, I. A., Charan, R., Purayil, S. B. P., Krishna, G., Kumar, A. P., & Sharma, R. (2018). Ameliorative effect of Chitosan-conjugated 17α-methyltestosterone on testicular development in Clarias batrachus. Anim Reprod Sci. 193:245-254.
  • Neeraj Kumar K.K. Krishnani Paritosh Kumara Rupam Sharma Raju Baitha Dilip Kumar Singh Narendra Pratap Singh, 2018. Dietary nano-silver: Does support or discourage thermal tolerance and biochemical status in air-breathing fish reared under multiple stressors? Journal of Thermal Biology, 77: 111-121
  • Neeraj Kumar, K.K. Krishnani, Sanjay Kumar Gupta, Rupam Sharma, Raju Baitha, Dilip Kumar Singh, Narendra Pratap Singha, (2018). Immuno-protective role of biologically synthesized dietary selenium nanoparticles against multiple stressors in Pangasinodon hypophthalmus. Fish and Shellfish Immunology, 78: 289–298
  • Nandanpawar P. C, Rather M. A, Badhe M. R, Sharma R. (2018). Assessment of DNA Damage During Gene Delivery in Freshwater Prawn by Chitosan Reduced Gold Nanoparticles. Orient J Chem 2018;34(2)
  • Mohd Ashraf Rather, Syed Hussain Basha, Irfan Ahmad Bhat, Niti Sharma, Priyanka Nandanpawar, Mohan Badhe, Jitendra Kumar Sundaray and Rupam Sharma- 2017. Characterization, molecular docking, dynamics simulation and metadynamics of kisspeptin receptor with kisspeptin International Journal of Biological Macromolecules 101: 241-253
  • Kumar, P., Bhat I.A., Rather, M.A., Gireesh-Babu, P., Suresh-Babu P and Sharma R (2017). Steroidogenic acute regulatory protein (StAR) gene expression construct: Development, nanodelivery and effect on reproduction inair-breathing catfish, Clarias batrachus. Pravesh. Int J. Biol Macromol. 104:1082–1090.
  • Bhat I.A., Rather, M.A., Mir I.N., Gireesh-Babu P, Gosawami, M., Sundaray J.K and Sharma, R. (2017). Characterization, molecular docking and expression of 3-beta-hydroxysteroid dehydrogenase during ontogenetic development and annual reproductive phases of gonads in Asian catfish (Clarias batrachus). Theriogenology 105:34-44.
  • Bhat I.A., Kumar P., Mir I.N., Gireesh-Babu P, Gosawami, M., Sundaray J.K and Sharma R (2017) Toxicological evaluation and effective dose selection of eurycomanone, a quassinoid of Eurycoma longifolia plant in fishes. Aquaculture 481:94–102.
  • Kole S, Anand D, Sharma R, Tripathi G, M M, KV R, Kadam Bedekar M, 2017. Tissue specific expression profile of some immune related genes in Labeo rohita to Edwardsiella tarda infection, Fish and Shellfish Immunology (2017), doi: 10.1016/j.fsi.2017.05.047
  • Niti Sharma, Mohd Ashraf Rather, Gireesh-Babu P., Kundan Kumar, Malachy N.O. Ajima and Rupam Sharma 2016. Assessment of DNA damage and molecular responses in Labeo rohita (Hamilton, 1822) following short-term exposure to silver nanoparticles. Food and chemical toxicology, 96:122-132
  • Mohd Ashraf Rather, Irfan Ahmad Bhat, Gireesh-Babu P, Aparna Chaudhari Jeetendra Kumar Sundaray and Rupam Sharma. 2016. In silico analysis and expression studies of Kisspeptin gene in fish. Journal of Biomolecular Structure & Dynamics (Impact Factor: 3.1) 2485-2496
  • MA Rather, IA Bhat, GB Pathakota, A Chaudhari, JK Sundaray, R Sharma, 2016. Molecular characterization of kisspeptin gene and effect of nano–encapsulted kisspeptin-10 on reproductive maturation in Catla catla. Domestic Animal Endocrinology, 56: 36-47

Ongoing Projects

Externally funded
  • Development of nanodelivery system of DNA based RNAi vaccine against WSSV in tiger shrimp Penaeus monodon. Dept of Biotechnology (DBT), Govt. of India. 1st Apr 2012 to 31st Mar 2015; PI: Rupam Sharma; Co-PIs: Aparna Chaudhari; Gireesh Babu P.
  • Genetic conservation and live gene banking of mahseer in Indrayani River. NAIP, ICAR, 1st Apr 2010 to 31st Mar 2015; PI: Gopal Krishna; Co-PI: Rupam Sharrma, CCCPI: S. Jahageerdar

Institute funded
  • Characterization and nano encapsulation of fish pheromones for using in fish reproduction, 1st Apr 2008 to 31st Mar 2011; PI: Rupam Sharma

Others