Dr. Rajendran K. V.
Principal Scientist
Division of A.E.H.M.
M. Sc., Ph. D
+91 22 26361446 | Extn: 503(O)
Research Interests
- Crustacean Viral Diseases and development of molecular diagnostics.
- Crustacean immune genes and understanding shrimp innate immune responses to WSSV.
Research Papers
- Deepika, A, Sreedharan, K., Rajendran, K.V. (2020) Responses of some innate immune-genes involved in the Toll-pathway in black tiger shrimp (Penaeus monodon) to Vibrio harveyi infection and on exposure to ligands in vitro. Journal of the World Aquaculture Society (In press)
- Kumari, P., Kumar, S., Ramesh M., Shameena S., Deo, A,D., Rajendran, K.V., Raman, R.P. (2019) Antiparasitic effect of aqueous and organic solvent extracts of Azadirachta indica leaf against Argulus japonicus in Carassius auratus. Aquaculture, https://doi.org/10.1016/j.aquaculture.2019.05.060.
- Qadiri, S.S.N., Makesh, M., Rajendran, K.V., Rathore G., Purushothaman, C.S. (2018) Specific immune response in mucosal and systemic compartments of Cirrhinus mrigala vaccinated against Edwardsiella tarda: In vivo kinetics using different antigen delivery routes. Journal of World Aquaculture Society. 1–10. https://doi. org/10.1111/jwas.12584
- Kumar, S., Raman, R.P., Prasad, K.P., Srivastava, P.P., Kumar, S., Rajendran, K.V., (2018) Effects on haematological and serum biochemical parameters of Pangasianodon hypophthalmus to an experimental infection of Thaparocleidus sp. (Monogenea: dactylogyridae), Experimental Parasitology, doi: 10.1016/j.exppara.2018.02.007.
- Paria, A., Makesh, M., Chaudhari, A., Purushothaman, C.S., Rajendran, K.V. (2018) Nucleotide-binding oligomerization domain-containing protein 1 (NOD1) in Asian seabass, Lates calcarifer: Cloning, ontogeny and expression analysis following bacterial infection or ligand stimulation. Fish & Shellfish Immunology. 79: 153-162
- Sreedharan, K., Deepika, A., Paria, A., Badekar, M. K., Makesh, M., Rajendran, K.V. (2018) Ontogenetic and expression of different genes involved in the Toll pathway of black tiger shrimp (Penaeus monodon) following immersion challenge with Vibrio harveyi and white spot syndrome virus (WSSV). Agri Gene, 8: 63-71.
- Kole, S., Kumari, R., Anand, D., Kumar S., Sharma R., Tripathi G., Makehs M., Rajendran, K.V., Bedekar M.K. (2018). Nanoconjugation of bicistronic DNA vaccine against Edwardsiella tarda using chitosan nanoparticles: Evaluation of its protective efficacy and immune modulatory effects in Labeo rohita vaccinated by different delivery routes. Vaccine 36 (16), 2155-2165.
- Paria, A., Makesh, M., Chaudhari, A., Purushothaman, C.S., Rajendran, K.V. (2018) Molecular characterisation, ontogeny and expression analysis of melanoma differentiation-associated factor 5 (MDA5) from Asian seabass, Lates calcarifer. Developmental and Comparative Immunology 78: 71-82
- Paria, A., Makesh, M., Chaudhari, A., Purushothaman, C.S. and Rajendran, K.V., 2017. Toll-like receptor (TLR) 22, a non-mammalian TLR in Asian seabass, Lates calcarifer: Characterisation, ontogeny and inductive expression upon exposure with bacteria and ligands. Developmental & Comparative Immunology. 81:180-186
- Kole, S., Deepika A., Sharma, R., Tripathi,G., Makesh, M., Rajendran, K.V. Bedekar, M.K. (2017) Tissue specific expression profile of some immune related genes in Labeo rohita to Edwardsiella tarda infection. Fish & Shellfish Immunology. 66: 575-582
- Kumar, S., Raman, R.P., Prasad, K.P., Srivastava, P.P., Kumar, S., Rajendran, K.V. (2017) Modulation of innate immune responses and induction of oxidative stress biomarkers in Pangasianodon hypophthalmus following an experimental infection with dactylogyrid monogeneans. Fish & Shellfish Immunology. 63: 334-343.
- Paria, A., Deepika, A., Sreedharan, K., Makesh, M., Chaudhari, A., Purushothaman, C.S., Rajendran, K.V. (2017) Identification, ontogeny and expression analysis of a novel laboratory of genetics and physiology 2 (LGP2) transcript in Asian seabass, Lates calcarifer. Fish & Shellfish Immunology. 62: 265-275.
- Srivastava, S., Dahal, S., Naidu, S., Deepika, A., Gopalakrishnan, V., Rajendran, K.V., and Raghavan, S.C. (2017) DNA double-strand break repair in Penaeus monodon is predominantly dependent on homologous recombination. DNA Research, 24(2):117-128.
- Sreedharan, K., Deepika, A., Anutosh Paria, Suresh Babu, P.P., Makesh, M., Rajendran, K.V.(2017) Ontogeny and expression analysis of tube (interleukin-1 receptor-associated kinase-4 homolog) from Penaeus monodon in response to white spot syndrome virus infection and on exposure to ligands. Agri Gene, 3: 21-31.
- Paria, A., Dong, J., Suresh Babu, P.P., Makesh, M., Chaudhari, A., Thirunavukkarasu, A.R., Purushothaman, C.S., Rajendran, K.V. (2016) Evaluation of candidate reference genes for quantitative expression studies in Asian seabass (Lates calcarifer); during ontogenesis and in tissues of healthy and infected fishes. Indian Journal of Experimental Biology, 54: 597-605.
- Paria, A., Deepika, A., Sreedharan, K., Makesh, M., Chaudhari, A., Purushothaman, C.S., Thirunavukkarasu, A.R., Rajendran, K.V. (2016) Identification of Nod like receptor C3 (NLRC3) in Asian seabass, Lates calcarifer: Characterisation, ontogeny and expression analysis after experimental infection and ligand stimulation. Fish & Shellfish Immunology 55: 602-612.
- Vidya, R., Makesh, M., Purushothaman, C.S., Chaudhari, A., Gireesh-Babu, P., Rajendran, K.V. (2016) Report of leucine-rich repeats (LRRs) from Scylla serrata: Ontogeny, molecular cloning, characterization and expression analysis following ligand stimulation, and upon bacterial and viral infections. Gene 590: 159–168.
- Rajendran, K.V., Shivam, S., Praveena, P.E., Rajan, J.J.S., Kumar, Avunje, V., Jagadeesan, S., Babu, P. S.V.A.N.V., Pande, A., Krishnan, A.N., Alavandi, S.V., Vijayan, K.K. (2016) Emergence of Enterocytozoon hepatopenaei (EHP) in farmed Penaeus (Litopenaeus) vannamei in India. Aquaculture 454: 272–280.
- Yadav, R., Paria, A., Mankame, S., Makesh, M., Chaudhari, A., Rajendran, K.V. (2015) Development of SYBR Green and TaqMan quantitative real-time PCR assays for hepatopancreatic parvovirus (HPV) infecting Penaeus monodon in India. Molecular and Cellular Probes. 29: 442-448. (Impact Factor: 1.565) ISSN: 0890-8508
- Bhat, A., Paria, A., Deepika, A., Sreedharan, K., Makesh, M., Bedekar, M.K., Purushothaman, C.S., Rajendran, K.V. (2015) Molecular cloning, characterisation and expression analysis of melanoma differentiation associated gene 5 (MDA5) of green chromide, Etroplus suratensis. Gene. 557(2): 172-181.
Research Projects undertaken- 2015-2020 (External-funding)
| Sr.No. | Title of the project | PI. / Co.PI |
Funding Agency | Period | Budget (in-lakh) |
|---|---|---|---|---|---|
| 1 | Understanding molecular basis of host-pathogen and environment interaction of Tilapia lake virus disease | PI | National Agricultural Science Fund (NASF) | 2019-2022 | 86.33776 |
| 2 | Characterization of mucosal immunoglobins in Tilapia and development of ELISA for diagnosis of Tilapia lake virus (TiLV) infection | Co-PI | Department of Biotechnology (DBT), Govt. of India | 2019-2021 | 34.84 |
| 3 | Development of energy-efficient and environment protective aquaculture technologies for degraded soils (Under Agricultural National Higher Education Project) | Co-PI | Agricultural National Higher Education Project (NAHEP)- Education Division of ICAR and World Bank | 2018-2021 | 1994.80 |
| 4 | Molecular screening, cell culture based isolation and characterization of finfish and shellfish viruses and establishment of National Repository | PI | Department of Biotechnology (DBT), Govt. of India | 2017-2020 | 98.683 |
| 5 | Novel molecular approaches for advancing prediction and mitigation of disease outbreaks in aquaculture for small scale farmers (International Collaborative Project) | PI | Department of Biotechnology (DBT), Govt. of India & BBSRC (UK) | 2016-2019 | 113.456 |
| 6 | Defence genes of tiger shrimp (Penaeus monodon) with respect to bacteria (Vibrio harveyi) and white spot virus (WSSV) infection | CCPI | National Fund for Basic, Strategic and Frontier Application Research (NFBSARA) | 2012-2016 | 71.44690 |
Research Projects undertaken as Co-PI (Institute-funding)
| No. | Title of the project | PI./Co.-PI | Period |
|---|---|---|---|
| 1 | Development of monoclonal antibody against Flavobacterium columnare and its use in rapid disease diagnosis (Project code: IXX15029) | Co-PI | 2019-2021 |
| 2 | Studies on important diseases of Clarias magur and to develop appropriate management strategies Project code: IXX15200) | Co-PI | 2019-2021 |
| 3 | Development of phytotherapy against Argulus parasite of fish (Project code: IXX13704) | Co-PI | 2017-2020 |
| 4 | Development of comprehensive package of practices of Inland saline water Aquaculture (Project code: IXX13705) Identification and characterization of potential pathogens, with emphasis on bacterial pathogens, of Penaeus vannamei cultivated in inland saline water for the development of an effective health management strategy | Co-PI | 2017-2018 |
| 5 | Enteric viral risk assessment of seafood (Project code: CIFE-2013/6) | Co-PI | - |
| 6 | Development of novel DNA vaccine construct against E. tarda (Project code: IXX08991) | Co-PI | 2013-2016 |